Neuropsychopharmacology & Psychobiology Research Group
Neuropsychopharmacology & Psychobiology                                                  Research Group

Plaza Fragela 9

Cádiz 11003 

Spain

News in Social Media World

Publications

  • Garcia-Bueno, B., Bioque, M., Mac-Dowell, K. S., Barcones, M. F., Martinez-Cengotitabengoa, M., Pina-Camacho, L., Rodriguez-Jimenez, R., Saiz, P. A., Castro, C., Lafuente, A., Santabarbara, J., Gonzalez-Pinto, A., Parellada, M., Rubio, G., Garcia-Portilla, M. P., Mico, J. A., Bernardo, M. & Leza, J. C. (2014) Pro-/Anti-inflammatory Dysregulation in Patients With First Episode of Psychosis: Toward an Integrative Inflammatory Hypothesis of Schizophrenia. Schizophr Bull 40(2): 376-387.

http://www.ncbi.nlm.nih.gov/pubmed/23486748

 

  • Bravo, L., Torres-Sanchez, S., Alba-Delgado, C., Mico, J. A. & Berrocoso, E. (2014) Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats. Eur Neuropsychopharmacol.

 http://www.ncbi.nlm.nih.gov/pubmed/24491949

 

  • Borges, G., Neto, F., Mico, J. A. & Berrocoso, E. (2014) Reversal of Monoarthritis-induced Affective Disorders by Diclofenac in Rats. Anesthesiology.

http://www.ncbi.nlm.nih.gov/pubmed/24534905

 

  • Uriguen, L., Gil-Pisa, I., Munarriz-Cuezva, E., Berrocoso, E., Pascau, J., Soto-Montenegro, M. L., Gutierrez-Adan, A., Pintado, B., Madrigal, J. L., Castro, E., Sanchez-Blazquez, P., Ortega, J. E., Guerrero, M. J., Ferrer-Alcon, M., Garcia-Sevilla, J. A., Mico, J. A., Desco, M., Leza, J. C., Pazos, A., Garzon, J. & Meana, J. J. (2013) Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia. Transl Psychiatry 3: e221.

http://www.ncbi.nlm.nih.gov/pubmed/23340504

 

  • Torres-Sanchez, S., Alba-Delgado, C., Llorca-Torralba, M., Mico, J. A. & Berrocoso, E. (2013) Effect of tapentadol on neurons in the locus coeruleus. Neuropharmacology 72: 250-258.

http://www.ncbi.nlm.nih.gov/pubmed/23664814

 

  • Sanchez-Blazquez, P., Rodriguez-Munoz, M., Berrocoso, E. & Garzon, J. (2013) The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain. Eur J Pharmacol 716(1-3): 94-105.

http://www.ncbi.nlm.nih.gov/pubmed/23499699

 

  • Salazar, A., Duenas, M., Mico, J. A., Ojeda, B., Aguera-Ortiz, L., Cervilla, J. A. & Failde, I. (2013) Undiagnosed mood disorders and sleep disturbances in primary care patients with chronic musculoskeletal pain. Pain Med 14(9): 1416-1425

http://www.ncbi.nlm.nih.gov/pubmed/23742219

 

  • Ramos-Rodriguez, J. J., Pacheco-Herrero, M., Thyssen, D., Murillo-Carretero, M. I., Berrocoso, E., Spires-Jones, T. L., Bacskai, B. J. & Garcia-Alloza, M. (2013) Rapid beta-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. J Neuropathol Exp Neurol 72(4): 272-285.

http://www.ncbi.nlm.nih.gov/pubmed/23481704

 

  • Ramos-Rodriguez, J. J., Ortiz, O., Jimenez-Palomares, M., Kay, K. R., Berrocoso, E., Murillo-Carretero, M. I., Perdomo, G., Spires-Jones, T., Cozar-Castellano, I., Lechuga-Sancho, A. M. & Garcia-Alloza, M. (2013) Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice. Psychoneuroendocrinology 38(11): 2462-2475

http://www.ncbi.nlm.nih.gov/pubmed/23790682

 

  • Ramos-Rodriguez, J. J., Molina-Gil, S., Rey-Brea, R., Berrocoso, E. & Garcia-Alloza, M. (2013) Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice. PLoS One 8(11): e79947. 

http://www.ncbi.nlm.nih.gov/pubmed/24278223

 

  • Perez-Caballero, L., Perez-Egea, R., Romero-Grimaldi, C., Puigdemont, D., Molet, J., Caso, J. R., Mico, J. A., Perez, V., Leza, J. C. & Berrocoso, E. (2013) Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs. Mol Psychiatry.

http://www.ncbi.nlm.nih.gov/pubmed/23711979

 

  • Perez, C., Ribera, M. V., Galvez, R., Mico, J. A., Barutell, C., Failde, I., Sanchez-Magro, I. & Stern, A. (2013) High prevalence of confirmed, but also of potential and believed, neuropathic pain in pain clinics. Eur J Pain 17(3): 347-356.

http://www.ncbi.nlm.nih.gov/pubmed/22927200

 

  • Miguelez, C., Berrocoso, E., Mico, J. A. & Ugedo, L. (2013) L-DOPA modifies the antidepressant-like effects of reboxetine and fluoxetine in rats. Neuropharmacology 67: 349-358

http://www.ncbi.nlm.nih.gov/pubmed/23211937

 

  • MacDowell, K. S., Garcia-Bueno, B., Madrigal, J. L., Parellada, M., Arango, C., Mico, J. A. & Leza, J. C. (2013) Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation. Int J Neuropsychopharmacol 16(1): 121-135.

http://www.ncbi.nlm.nih.gov/pubmed/22176740

 

  • Garate, I., Garcia-Bueno, B., Madrigal, J. L., Caso, J. R., Alou, L., Gomez-Lus, M. L., Mico, J. A. & Leza, J. C. (2013) Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway. Biol Psychiatry 73(1): 32-43.

http://www.ncbi.nlm.nih.gov/pubmed/22906518

 

  • Failde, I., Duenas, M., Aguera-Ortiz, L., Cervilla, J. A., Gonzalez-Pinto, A. & Mico, J. A. (2013) Factors associated with chronic pain in patients with bipolar depression: a cross-sectional study. BMC Psychiatry 13: 112.

http://www.ncbi.nlm.nih.gov/pubmed/23587328

 

  • Bravo, L., Alba-Delgado, C., Torres-Sanchez, S., Mico, J. A., Neto, F. L. & Berrocoso, E. (2013) Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: the role of the locus coeruleus. Pain 154(10): 2014-2023.

http://www.ncbi.nlm.nih.gov/pubmed/23792242

 

  • Borges, G. S., Berrocoso, E., Ortega-Alvaro, A., Mico, J. A. & Neto, F. L. (2013) Extracellular signal-regulated kinase activation in the chronic constriction injury model of neuropathic pain in anaesthetized rats. Eur J Pain 17(1): 35-45

http://www.ncbi.nlm.nih.gov/pubmed/23055268

 

  • Berrocoso, E., Ikeda, K., Sora, I., Uhl, G. R., Sanchez-Blazquez, P. & Mico, J. A. (2013) Active behaviours produced by antidepressants and opioids in the mouse tail suspension test. Int J Neuropsychopharmacol 16(1): 151-162.

http://www.ncbi.nlm.nih.gov/pubmed/22217458

 

  • Alba-Delgado, C., Llorca-Torralba, M., Horrillo, I., Ortega, J. E., Mico, J. A., Sanchez-Blazquez, P., Meana, J. J. & Berrocoso, E. (2013) Chronic pain leads to concomitant noradrenergic impairment and mood disorders. Biol Psychiatry 73(1): 54-62

http://www.ncbi.nlm.nih.gov/pubmed/22854119

 

  • Aguera-Ortiz, L., Failde, I., Cervilla, J. A. & Mico, J. A. (2013) Unexplained pain complaints and depression in older people in primary care. J Nutr Health Aging 17(6): 574-577

http://www.ncbi.nlm.nih.gov/pubmed/23732555

 

  • Torres-Sanchez, S., Perez-Caballero, L., Mico, J. A., Elorza, J. & Berrocoso, E. (2012) Preclinical discovery of duloxetine for the treatment of depression. Expert Opin Drug Discov 7(8): 745-755.

http://www.ncbi.nlm.nih.gov/pubmed/22680253

 

  • Rodriguez-Munoz, M., Sanchez-Blazquez, P., Vicente-Sanchez, A., Berrocoso, E. & Garzon, J. (2012) The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacology 37(2): 338-349.

http://www.ncbi.nlm.nih.gov/pubmed/21814188

 

  • Ortega-Alvaro, A., Berrocoso, E., Rey-Brea, R., Leza, J. C. & Mico, J. A. (2012) Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain. Life Sci 90(1-2): 13-20.

http://www.ncbi.nlm.nih.gov/pubmed/22036619

 

  • Mico, J. A. & Prieto, R. (2012) Elucidating the mechanism of action of pregabalin: alpha(2)delta as a therapeutic target in anxiety. CNS Drugs 26(8): 637-648

http://www.ncbi.nlm.nih.gov/pubmed/22784017

 

  • Martinez-Cengotitabengoa, M., Mac-Dowell, K. S., Leza, J. C., Mico, J. A., Fernandez, M., Echevarria, E., Sanjuan, J., Elorza, J. & Gonzalez-Pinto, A. (2012) Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes. Schizophr Res 137(1-3): 66-72.

http://www.ncbi.nlm.nih.gov/pubmed/22445462

 

  • Gonzalez-Pinto, A., Martinez-Cengotitabengoa, M., Arango, C., Baeza, I., Otero-Cuesta, S., Graell-Berna, M., Soutullo, C., Leza, J. C. & Mico, J. A. (2012) Antioxidant defense system and family environment in adolescents with family history of psychosis. BMC Psychiatry 12: 200.

http://www.ncbi.nlm.nih.gov/pubmed/23158023

 

  • Fraguas, D., Gonzalez-Pinto, A., Mico, J. A., Reig, S., Parellada, M., Martinez-Cengotitabengoa, M., Castro-Fornieles, J., Rapado-Castro, M., Baeza, I., Janssen, J., Desco, M., Leza, J. C. & Arango, C. (2012) Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study. Schizophr Res 137(1-3): 58-65.

http://www.ncbi.nlm.nih.gov/pubmed/22365149

 

  • Bravo, L., Mico, J. A., Rey-Brea, R., Perez-Nievas, B., Leza, J. C. & Berrocoso, E. (2012) Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression. Anesthesiology 117(3): 613-625

http://www.ncbi.nlm.nih.gov/pubmed/22846678

 

  • Alba-Delgado, C., Mico, J. A., Sanchez-Blazquez, P. & Berrocoso, E. (2012) Analgesic antidepressants promote the responsiveness of locus coeruleus neurons to noxious stimulation: implications for neuropathic pain. Pain 153(7): 1438-1449.

http://www.ncbi.nlm.nih.gov/pubmed/22591831

 

  • Alba-Delgado, C., Borges, G., Sanchez-Blazquez, P., Ortega, J. E., Horrillo, I., Mico, J. A., Meana, J. J., Neto, F. & Berrocoso, E. (2012) The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology (Berl) 221(1): 53-65.

http://www.ncbi.nlm.nih.gov/pubmed/22038538

 

  • Neto, F. L., Borges, G., Torres-Sanchez, S., Mico, J. A. & Berrocoso, E. (2011) Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol 9(4): 530-552

 

http://www.ncbi.nlm.nih.gov/pubmed/22654714

 

  • Mico, J. A., Rojas-Corrales, M. O., Gibert-Rahola, J., Parellada, M., Moreno, D., Fraguas, D., Graell, M., Gil, J., Irazusta, J., Castro-Fornieles, J., Soutullo, C., Arango, C., Otero, S., Navarro, A., Baeza, I., Martinez-Cengotitabengoa, M. & Gonzalez-Pinto, A. (2011) Reduced antioxidant defense in early onset first-episode psychosis: a case-control study. BMC Psychiatry 11: 26.

http://www.ncbi.nlm.nih.gov/pubmed/21320302

 

  • Mico, J. A., Berrocoso, E., Vitton, O., Ladure, P., Newman-Tancredi, A., Bardin, L. & Depoortere, R. (2011) Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model. Behav Pharmacol 22(5-6): 599-606.

http://www.ncbi.nlm.nih.gov/pubmed/21841543

 

  • Martinez-Cengotitabengoa, M., Besga, A., Fernandez, M., Mico, J. A. & Gonzalez-Pinto, A. (2011) Adverse drug events in older adults: development of a predictive model. J Am Geriatr Soc 59(9): 1761-1763

http://www.ncbi.nlm.nih.gov/pubmed/22136543

 

  • Garate, I., Garcia-Bueno, B., Madrigal, J. L., Bravo, L., Berrocoso, E., Caso, J. R., Mico, J. A. & Leza, J. C. (2011) Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression. J Neuroinflammation 8: 151.

http://www.ncbi.nlm.nih.gov/pubmed/22053929

 

  • Emery, E. C., Young, G. T., Berrocoso, E. M., Chen, L. & McNaughton, P. A. (2011) HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science 333(6048): 1462-1466

http://www.ncbi.nlm.nih.gov/pubmed/21903816

 

  • Berrocoso, E., Mico, J. A., Vitton, O., Ladure, P., Newman-Tancredi, A., Depoortere, R. & Bardin, L. (2011) Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. Eur J Pharmacol 655(1-3): 46-51.

http://www.ncbi.nlm.nih.gov/pubmed/21277295

 

  • Aguera-Ortiz, L., Failde, I., Mico, J. A., Cervilla, J. & Lopez-Ibor, J. J. (2011) Pain as a symptom of depression: prevalence and clinical correlates in patients attending psychiatric clinics. J Affect Disord 130(1-2): 106-112

http://www.ncbi.nlm.nih.gov/pubmed/21055826

 

  • Vergel, N. E., Lopez, J. L., Orallo, F., Vina, D., Buitrago, D. M., del Olmo, E., Mico, J. A. & Guerrero, M. F. (2010) Antidepressant-like profile and MAO-A inhibitory activity of 4-propyl-2H-benzo[h]-chromen-2-one. Life Sci 86(21-22): 819-824

http://www.ncbi.nlm.nih.gov/pubmed/20394758

 

  • Prieto, E., Mico, J. A., Meana, J. J. & Majadas, S. (2010) Neurobiological bases of quetiapine antidepresant effect in the bipolar disorder. Actas Esp Psiquiatr 38(1): 22-32.

http://www.ncbi.nlm.nih.gov/pubmed/20931407

 

  • Aguera, L., Failde, I., Cervilla, J. A., Diaz-Fernandez, P. & Mico, J. A. (2010) Medically unexplained pain complaints are associated with underlying unrecognized mood disorders in primary care. BMC Fam Pract 11: 17

http://www.ncbi.nlm.nih.gov/pubmed/20199657

 

  • Moreno Brea, M. A. & Mico, J. A. (2009) [TNF and cytokines and pain: Beyond the tisular inflammation]. Reumatol Clin 5 Suppl 2: 1-4.

http://www.ncbi.nlm.nih.gov/pubmed/21794649

 

  • Berrocoso, E., Sanchez-Blazquez, P., Garzon, J. & Mico, J. A. (2009) Opiates as antidepressants. Curr Pharm Des 15(14): 1612-1622

http://www.ncbi.nlm.nih.gov/pubmed/19442177

 

  • Berrocoso, E. & Mico, J. A. (2009) Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice. Int J Neuropsychopharmacol 12(1): 61-71

http://www.ncbi.nlm.nih.gov/pubmed/18405417

 

  • Berrocoso, E. & Mico, J. A. (2009) Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression. Int J Neuropsychopharmacol 12(8): 1033-1044

http://www.ncbi.nlm.nih.gov/pubmed/19341511

 

  • Rojas-Corrales, M. O., Gibert-Rahola, J. & Mico, J. A. (2007) Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology (Berl) 190(2): 221-231.

http://www.ncbi.nlm.nih.gov/pubmed/17102981

 

  • Berrocoso, E. & Mico, J. A. (2007) In vivo effect of venlafaxine on locus coeruleus neurons: role of opioid, alpha(2)-adrenergic, and 5-hydroxytryptamine(1A) receptors. J Pharmacol Exp Ther 322(1): 101-107

http://www.ncbi.nlm.nih.gov/pubmed/17431134

 

  • Berrocoso, E., De Benito, M. D. & Mico, J. A. (2007) Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. Psychopharmacology (Berl) 193(1): 97-105

http://www.ncbi.nlm.nih.gov/pubmed/17393145

 

  • Ortega-Alvaro, A., Gibert-Rahola, J. & Mico, J. A. (2006) Influence of chronic treatment with olanzapine, clozapine and scopolamine on performance of a learned 8-arm radial maze task in rats. Prog Neuropsychopharmacol Biol Psychiatry 30(1): 104-111.

http://www.ncbi.nlm.nih.gov/pubmed/16226364

 

  • Mico, J. A., Berrocoso, E., Ortega-Alvaro, A., Gibert-Rahola, J. & Rojas-Corrales, M. O. (2006) The role of 5-HT1A receptors in research strategy for extensive pain treatment. Curr Top Med Chem 6(18): 1997-2003.

http://www.ncbi.nlm.nih.gov/pubmed/17017970

 

  • Mico, J. A., Ardid, D., Berrocoso, E. & Eschalier, A. (2006) Antidepressants and pain. Trends Pharmacol Sci 27(7): 348-354

http://www.ncbi.nlm.nih.gov/pubmed/16762426

 

  • Berrocoso, E., Rojas-Corrales, M. O. & Mico, J. A. (2006) Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice. Psychopharmacology (Berl) 188(1): 111-118.

http://www.ncbi.nlm.nih.gov/pubmed/16832657

 

  • Berrocoso, E., Mico, J. A. & Ugedo, L. (2006) In vivo effect of tramadol on locus coeruleus neurons is mediated by alpha2-adrenoceptors and modulated by serotonin. Neuropharmacology 51(1): 146-153.

http://www.ncbi.nlm.nih.gov/pubmed/16730359

 

  • Rojas-Corrales, M. O., Berrocoso, E. & Mico, J. A. (2005) Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol. Eur J Pharmacol 511(1): 21-26.

http://www.ncbi.nlm.nih.gov/pubmed/15777775

 

  • Muriel, C., Failde, I., Mico, J. A., Neira, M. & Sanchez-Magro, I. (2005) Effectiveness and tolerability of the buprenorphine transdermal system in patients with moderate to severe chronic pain: a multicenter, open-label, uncontrolled, prospective, observational clinical study. Clin Ther 27(4): 451-462.

http://www.ncbi.nlm.nih.gov/pubmed/15922818

 

  • Rojas-Corrales, M. O., Berrocoso, E., Gibert-Rahola, J. & Mico, J. A. (2004) Antidepressant-like effect of tramadol and its enantiomers in reserpinized mice: comparative study with desipramine, fluvoxamine, venlafaxine and opiates. J Psychopharmacol 18(3): 404-411.

http://www.ncbi.nlm.nih.gov/pubmed/15358985

 

  • Ortega-Alvaro, A., Acebes, I., Saracibar, G., Echevarria, E., Casis, L. & Mico, J. A. (2004) Effect of the antidepressant nefazodone on the density of cells expressing mu-opioid receptors in discrete brain areas processing sensory and affective dimensions of pain. Psychopharmacology (Berl) 176(3-4): 305-311.

http://www.ncbi.nlm.nih.gov/pubmed/15138764

 

  • Gonzalez-Pinto, A., van Os, J., Peralta, V., Perez de Heredia, J. L., Mosquera, F., Aldama, A., Gonzalez, C., Gutierrez, M. & Mico, J. A. (2004) The role of age in the development of Schneiderian symptoms in patients with a first psychotic episode. Acta Psychiatr Scand 109(4): 264-268.

http://www.ncbi.nlm.nih.gov/pubmed/15008799

 

  • Berrocoso, E., Rojas-Corrales, M. O. & Mico, J. A. (2004) Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice. Neurosci Lett 363(1): 25-28.

http://www.ncbi.nlm.nih.gov/pubmed/15157989

 

  • Rojas-Corrales, M. O., Casas, J., Moreno-Brea, M. R., Gibert-Rahola, J. & Mico, J. A. (2003) Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites. Eur Neuropsychopharmacol 13(5): 355-363.

http://www.ncbi.nlm.nih.gov/pubmed/12957334

 

  • Roca-Vinardell, A., Ortega-Alvaro, A., Gibert-Rahola, J. & Mico, J. A. (2003) The role of 5-HT1A/B autoreceptors in the antinociceptive effect of systemic administration of acetaminophen. Anesthesiology 98(3): 741-747

http://www.ncbi.nlm.nih.gov/pubmed/12606921

 

  • Gutierrez, M., Ortega-Alvaro, A., Gibert-Rahola, J. & Mico, J. A. (2003) Interactions of acute morphine with chronic imipramine and fluvoxamine treatment on the antinociceptive effect in arthritic rats. Neurosci Lett 352(1): 37-40.

http://www.ncbi.nlm.nih.gov/pubmed/14615044

 

  • Gonzalez-Pinto, A., van Os, J., Perez de Heredia, J. L., Mosquera, F., Aldama, A., Lalaguna, B., Gutierrez, M. & Mico, J. A. (2003) Age-dependence of Schneiderian psychotic symptoms in bipolar patients. Schizophr Res 61(2-3): 157-162.

http://www.ncbi.nlm.nih.gov/pubmed/12729867

 

  • Rojas-Corrales, M. O., Berrocoso, E., Gibert-Rahola, J. & Mico, J. A. (2002) Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats. Life Sci 72(2): 143-152.

http://www.ncbi.nlm.nih.gov/pubmed/12417248

 

  • Gonzalez-Pinto, A., Tohen, M., Lalaguna, B., Perez-Heredia, J. L., Fernandez-Corres, B., Gutierrez, M. & Mico, J. A. (2002) Treatment of bipolar I rapid cycling patients during dysphoric mania with olanzapine. J Clin Psychopharmacol 22(5): 450-454

http://www.ncbi.nlm.nih.gov/pubmed/12352266

 

  • Gonzalez-Pinto, A., Gutierrez, M., Gonzalez, N., Elizagarate, E., Perez de Heredia, J. L. & Mico, J. A. (2002) Efficacy and safety of venlafaxine-ECT combination in treatment-resistant depression. J Neuropsychiatry Clin Neurosci 14(2): 206-209.

http://www.ncbi.nlm.nih.gov/pubmed/11983797

 

  • Gonzalez-Pinto, A., Imaz, H., De Heredia, J. L., Gutierrez, M. & Mico, J. A. (2001) Mania and tramadol-fluoxetine combination. Am J Psychiatry 158(6): 964-965.

http://www.ncbi.nlm.nih.gov/pubmed/11384912

 

  • Bano, M. D., Mico, J. A., Agujetas, M., Lopez, M. L. & Guillen, J. L. (2001) [Olanzapine efficacy in the treatment of cocaine abuse in methadone maintenance patients. Interaction with plasma levels]. Actas Esp Psiquiatr 29(4): 215-220.

http://www.ncbi.nlm.nih.gov/pubmed/11470055

 

  • Alvarez-Fuentes, J., Rojas -Corrales, M. O., Holgado, M. A., Sanchez-Lafuente, C., Mico, J. A. & Fernandez -Arevalo, M. (2001) Effectiveness of repeated administration of a new oral naltrexone controlled-release system on morphine analgesia. J Pharm Pharmacol 53(9): 1201-1205.

http://www.ncbi.nlm.nih.gov/pubmed/11578102

 

  • Rojas-Corrales, M. O., Ortega-Alvaro, A., Gibert-Rahola, J., Roca-Vinardell, A. & Mico, J. A. (2000) Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, enhances the analgesic effect of tramadol. Pain 88(2): 119-124.

http://www.ncbi.nlm.nih.gov/pubmed/11050366

 

  • Pernia, A., Mico, J. A., Calderon, E. & Torres, L. M. (2000) Venlafaxine for the treatment of neuropathic pain. J Pain Symptom Manage 19(6): 408-410.

http://www.ncbi.nlm.nih.gov/pubmed/10991644

 

  • Alvarez-Fuentes, J., Rojas-Corrales, M. O., Holgado, M. A., Caraballo, I., Mico, J. A. & Fernandez-Arevalo, M. (2000) Preclinical study of an oral controlled release naltrexone complex in mice. J Pharm Pharmacol 52(6): 659-663.

http://www.ncbi.nlm.nih.gov/pubmed/10875542

 

  • Moreno Brea, M. R., Rojas Corrales, O., Gibert-Rahola, J. & Mico, J. A. (1999) [Drug interactions of methadone with CNS-active agents]. Actas Esp Psiquiatr 27(2): 103-110.

http://www.ncbi.nlm.nih.gov/pubmed/10380152

 

  • Tejedor-Real, P., Mico, J. A., Smadja, C., Maldonado, R., Roques, B. P. & Gilbert-Rahola, J. (1998) Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. Eur J Pharmacol 354(1): 1-7.

http://www.ncbi.nlm.nih.gov/pubmed/9726624

 

  • Rojas-Corrales, M. O., Gibert-Rahola, J. & Mico, J. A. (1998) Tramadol induces antidepressant-type effects in mice. Life Sci 63(12): PL175-180.

http://www.ncbi.nlm.nih.gov/pubmed/9749830

 

  • Ortega-Alvaro, A., Chover-Gonzalez, A. J., Lai-Kuen, R., Mico, J. A., Gibert-Rahola, J., Fournie-Zaluski, M. C., Roques, B. P. & Maldonado, R. (1998) Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord. Eur J Pharmacol 356(2-3): 139-148.

http://www.ncbi.nlm.nih.gov/pubmed/9774243

 

  • Ortega-Alvaro, A., Gibert-Rahola, J., Mellado-Fernandez, M. L., Chover, A. J. & Mico, J. A. (1997) The effects of different monoaminergic antidepressants on the analgesia induced by spinal cord adrenal medullary transplants in the formalin test in rats. Anesth Analg 84(4): 816-820.

http://www.ncbi.nlm.nih.gov/pubmed/9085964

 

  • Mico, J. A., Gibert-Rahola, J., Casas, J., Rojas, O., Serrano, M. I. & Serrano, J. S. (1997) Implication of beta 1- and beta 2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants. Eur Neuropsychopharmacol 7(2): 139-145.

http://www.ncbi.nlm.nih.gov/pubmed/9169301

 

  • Tejedor-Real, P., Mico, J. A., Corbalan, J. P., Ruz-Franzi, I., Gonzalez-Darder, J. M. & Gibert-Rahola, J. (1996) Attenuation of learned helplessness in rats after transplant of adrenal medulla into the spinal cord. Eur Psychiatry 11(5): 249-253.

http://www.ncbi.nlm.nih.gov/pubmed/19698460

 

  • Mellado, M. L., Gibert-Rahola, J., Chover, A. J. & Mico, J. A. (1996) Effect on nociception of intracerebroventricular administration of low doses of neuropeptide Y in mice. Life Sci 58(26): 2409-2414.

http://www.ncbi.nlm.nih.gov/pubmed/8691985

 

  • Valverde, O., Maldonado, R., Mico, J. A. & Gibert-Rahola, J. (1995) Study of the mechanisms involved in behavioral changes induced by flunitrazepam in morphine withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 19(5): 973-991.

http://www.ncbi.nlm.nih.gov/pubmed/8539433

 

  • Tejedor-Real, P., Mico, J. A., Maldonado, R., Roques, B. P. & Gibert-Rahola, J. (1995) Implication of endogenous opioid system in the learned helplessness model of depression. Pharmacol Biochem Behav 52(1): 145-152.

http://www.ncbi.nlm.nih.gov/pubmed/7501657

 

  • Moreno-Brea, M. R., Gibert-Rahola, J. & Mico, J. A. (1995) Influence of antidepressant drugs administration on the morphine inhibitory effect in mice vasa deferentia. Life Sci 57(21): PL339-345.

http://www.ncbi.nlm.nih.gov/pubmed/7475937

 

  • Costela, C., Tejedor-Real, P., Mico, J. A. & Gibert-Rahola, J. (1995) Effect of neonatal handling on learned helplessness model of depression. Physiol Behav 57(2): 407-410.

http://www.ncbi.nlm.nih.gov/pubmed/7716225

 

  • Casas, J., Gibert-Rahola, J., Chover, A. J. & Mico, J. A. (1995) Test-dependent relationship of the antidepressant and analgesic effects of amitriptyline. Methods Find Exp Clin Pharmacol 17(9): 583-588.

http://www.ncbi.nlm.nih.gov/pubmed/8786671

 

  • Valverde, O., Mico, J. A., Maldonado, R., Mellado, M. & Gibert-Rahola, J. (1994) Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice. Prog Neuropsychopharmacol Biol Psychiatry 18(6): 1073-1092.

http://www.ncbi.nlm.nih.gov/pubmed/7824761

 

  • Ortega-Alvaro, A., Gibert-Rahola, J., Gonzalez-Darder, J. M. & Mico, J. A. (1994) [Amitriptyline facilitates the analgesic effect of adrenal medulla autograft in the lumbar subarachnoid space of the rat]. Rev Esp Anestesiol Reanim 41(6): 313-316.

http://www.ncbi.nlm.nih.gov/pubmed/7838997

 

  • Ortega-Alvaro, A., Gibert-Rahola, J., Chover, A. J., Tejedor-Real, P., Casas, J. & Mico, J. A. (1994) Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space as measured by an experimental model of acute pain. Exp Neurol 130(1): 9-14

http://www.ncbi.nlm.nih.gov/pubmed/7529714

 

  • Tejedor-Real, P., Mico, J. A., Maldonado, R., Roques, B. P. & Gibert-Rahola, J. (1993) Effect of mixed (RB 38A) and selective (RB 38B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat. Biol Psychiatry 34(1-2): 100-107.

http://www.ncbi.nlm.nih.gov/pubmed/8373929

 

  • Valverde, O., Mico, J. A., Maldonado, R. & Gibert-Rahola, J. (1992) Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice. Drug Alcohol Depend 30(3): 293-300.

http://www.ncbi.nlm.nih.gov/pubmed/1327709

 

  • Maldonado, R., Mico, J. A., Valverde, O., Saavedra, M. C., Leonsegui, I. & Gibert-Rahola, J. (1991) Influence of different benzodiazepines on the experimental morphine abstinence syndrome. Psychopharmacology (Berl) 105(2): 197-203.

http://www.ncbi.nlm.nih.gov/pubmed/1686654

 

  • Esteban, J., Chover, A. J., Sanchez, P. A., Mico, J. A. & Gibert-Rahola, J. (1989) Central administration of neuropeptide Y induces hypothermia in mice. Possible interaction with central noradrenergic systems. Life Sci 45(25): 2395-2400.

http://www.ncbi.nlm.nih.gov/pubmed/2607885

 

  • Gibert-Rahola, J., Maldonado, R., Mico, J. A., Leonsegui, I. & Saavedra, M. C. (1988) Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome. Prog Neuropsychopharmacol Biol Psychiatry 12(6): 927-933.

http://www.ncbi.nlm.nih.gov/pubmed/3241876

 

  • Steru, L., Chermat, R., Thierry, B., Mico, J. A., Lenegre, A., Steru, M., Simon, P. & Porsolt, R. D. (1987) The automated Tail Suspension Test: a computerized device which differentiates psychotropic drugs. Prog Neuropsychopharmacol Biol Psychiatry 11(6): 659-671

http://www.ncbi.nlm.nih.gov/pubmed/2894041

 

  • Hamon, M., Gozlan, H., Bourgoin, S., Benoliel, J. J., Mauborgne, A., Taquet, H., Cesselin, F. & Mico, J. A. (1987) Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology 26(6): 531-539.

http://www.ncbi.nlm.nih.gov/pubmed/3037421

 

  • Steru, L., Chermat, R., Millet, B., Mico, J. A. & Simon, P. (1986) Comparative study in mice of ten 1,4-benzodiazepines and of clobazam: anticonvulsant, anxiolytic, sedative, and myorelaxant effects. Epilepsia 27 Suppl 1: S14-17.

http://www.ncbi.nlm.nih.gov/pubmed/2874986

 

  • Chermat, R., Thierry, B., Mico, J. A., Steru, L. & Simon, P. (1986) Adaptation of the tail suspension test to the rat. J Pharmacol 17(3): 348-350.

http://www.ncbi.nlm.nih.gov/pubmed/3795979

 

  • Brochet, D., Mico, J. A., Martin, P. & Simon, P. (1986) Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice. Psychopharmacology (Berl) 88(4): 527-528.

http://www.ncbi.nlm.nih.gov/pubmed/3010364

 

  • Gilbert-Rahola, J., Galiana, J. & Mico, J. A. (1985) [Psychopharmacology of pain]. Actas Luso Esp Neurol Psiquiatr Cienc Afines 13(6): 358-360.

http://www.ncbi.nlm.nih.gov/pubmed/3834780

           

 

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